|Monster Type||Guts and Brains|
|Floors of Appearance|| Depths|
|Deals Contact Damage|| Yes|
|Type of Tears||None|
The Brain is an enemy in The Binding of Isaac: Rebirth that is commonly found on The Depths, the Necropolis, The Womb, and the Utero floors. It is a large brain.
- The Brain crawls around the room randomly, leaving a trail of creep behind it that lasts relatively long. When the Brain is near the player, it will crawl towards the player.