| Base Health|
| Base Damage||4.20|
| Base Fire Rate||1.00|
| Base Range||17.75|
| Base Speed||1.30|
| Base Shot Speed||2.00|
| Base Luck||1.00|
|Unlocked By||55 Pennies Collected in One Run|
Cain is a playable character in The Binding of Isaac: Rebirth.
He starts with the passive collectible Lucky Foot and one key. Cain has the highest movement speed out of all of the playable characters, but he is also one of the ones with the shortest range - tied with Azazel and Lazarus. Cain also has the highest luck stat out of all the playable characters.
- Cain is a reference to the biblical figure Cain, firstborn son of Adam and Eve and he who committed the first murder, the victim being his brother Abel.
- Abel can be found as an unlockable item, appearing as a dead, disembodied head.