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Crack
"...watching through a crack in his door..."
This article is currently under heavy maintenance and construction. It will be completed soon.

Collectibles are split into two categories: Passive, which directly affect the character, and Active, which the player manually uses to cause an effect.

Passive Collectibles

Passive items are items that neither need to be charged nor take up the spacebar item slot. Most directly and automatically affect the character, sometimes even changing their appearance.

Item Icon Item Pool Effect
<3  Heart Passive
HP up
Item Room; Gluttony

Adds one Red Heart Container and fully restores all Red Heart Containers.

???'s Only Friend Blue Baby&#039;s Only Friend
Controlled friend
Item Room

Familiar that is controlled via the arrow keys, dealing contact damage.

1 Up 1 Up
Extra Life
Secret Room

Gives the player an extra life.

20/20 20 20
Double shot
Item Room

Double-shot; Isaac shoots two tears at the same time.

3 Dollar Bill 3 Dollar Bill
Rainbow tears
Item Room

Random tear effects for every room. Possible effects: Fire Mind, Spoon Bender, My Reflection, Ouija Board, 20/20, Inner Eye, Iron Bar, Death's Touch, Scorpio, Tough Love, Proptosis, Number One, Mom's Contacts, Ball of Tar, Sagittarius.

9 Volt 9 Volt
Quicker charge
Shop

Gives the player 1 bar of charge upon use of their Active Item. Items that originally have only one charge bar will now recharge over time after each use.

Abaddon Abaddon
Evil up + DMG up + fear shot
Devil Room

Removes all Red Heart Containers and gives the player 6 black hearts. Raises Damage stat by 1.5 and Speed stat by 0.2. Tears can induce fear effect depending on Luck stat.

Abel Abel
Mirrored buddy
Item Room; Golden Chest

A familiar that mirrors the player's movements and shoots tears in the opposite direction as the player. Abel deals as much damage as Isaac's base damage.

Anemic Anemic
Toxic blood
Item Room

Adds 5 to the player's Range stat. When the player is damaged, they will leave a trail of creep behind them for the duration of the room.

Ankh Ankh
Eternal life?
Item Room

The player respawns as ??? upon death. ??? starts with 3 Soul Hearts and cannot ever gain red Heart Containers. This resurrection can only occur once.

Anti-Gravity Anti-Gravity
Antigravity tears + tears up
Item Room

Adds 0.32 to the player's Tears stat. Shots that the player fires will remain stationary until the player ceases fire, in which the floating tears will be propelled in the direction that they were originally fired. If afloat for too long, the tears will automatically propel themselves.

Aquarius Aquarius
A trail of tears
Item Room

The player leaves a trail of tears (creep) behind them.

Aries Aries
Ramming speed
Item Room

Adds 0.25 to the player's Speed stat. If the player gains enough speed, they can deal 18 contact damage.

Ball of Bandages Ball of Bandages
Gotta lick em all
Horsemen

Each time the player picks up Ball of Bandages, it will advance a stage. Ball of Bandages' stages are as follows:
1. An orbital familiar that blocks shots and deals contact damage.
2. An orbital familiar that blocks shots, deals contact damage, and shoots charm tears.
3. An enemy-chasing familiar that shoots charm tears.

Ball of Tar Ball of Tar
Sticky feet...
Item Room

The player leaves a trail of slowing tar (creep) behind them. Tears have a chance to apply a slowing effect on enemies, this depending on the player's Luck stat.

The Battery Battery Passive
Stores energy
Shop

Active items can be overcharged (charging twice, basically 2x charge bars). Extra charges are yellow instead of the usual green.

BBF BBF
Big beautiful fly
Item Room

Large familiar that bounces around the room, exploding on contact and dealing 70 damage. Disappears upon exploding, but later respawns.

The Belt Belt
Speed up
Boss Room

Adds 0.3 to the player's Speed stat.

Best Bud Best Bud
Sworn protector
Item Room; Key Beggar

When the player takes damage, an attack fly will orbit around them.

BFFs! BFFs
Your friends rule!
Shop; Key Beggar

The player's familiars (with the exception of Rotten Baby) are much bigger and deal twice as much damage than before.

Big Fan Big Fan
Fat protector
Item Room

A large, orbiting familiar that blocks tears. Slows down other orbitals. Can block brimstone lasers. Does not count as an orbital, allowing the player to have up to four orbitals.

The Black Bean Black Bean
Toot on touch
Item Room; Beggar

Upon taking damage, the player releases a toxic cloud of flatulence that causes a total of 26 damage over time.

Black Candle Black Candle
Curse of immunity + evil up
Shop; Curse Room

Gives the player a Black Heart and immunity to all curses. Also increases the chance of a Devil Room appearing after a boss fight.

Black Lotus Black Lotus
HP up x3
Secret Room

Gives the player a Red Heart Container, a Soul Heart, and a Black Heart.

Blood Bag Blood Bag
HP up
Blood Donation Machine

Gives the player one Red Heart Container, then restores 5 Red Hearts.

Blood Clot Blood Clot
DMG + range up
Boss Room

Increases the player's damage by 1.0 and range by 5.0 for their left eye only. If the player only has one source of tears, there will be a 50% chance that the stat improvements above are applied to that tear.

Blood of the Martyr Blood of the Martyr
DMG up
Item Room

Increases the player's damage by 1.0. If the player possesses The Book of Belial, the player's damage is also multiplied by 1.5. A Devil Room or Angel Room has a 100% chance to spawn after a boss battle.

Bloody Lust Bloody Lust
RAGE!
Item Room

Upon taking damage, the player's damage increases and Isaac turns a shade of red, this red color becoming darker each time the player takes damage. The damage increase reaches a maximum of 6.5, achieved by taking damage six times. This damage increase and red color only lasts for the current floor and will be reset upon advancing to the next floor.

Blue Cap Blue Cap
HP + tears + shot speed down
Boss Room

Gives the player a Red Heart Container and adds 0.7 to the player's Tears stat. The player's Shot Speed stat is lowered by 0.16.

Blue Map Blue Map
Secrets
Shop; Beggar; Key Beggar

Shows on the map both the Secret and Top Secret rooms for the current floor and later floors.

Bob's Brain Bob&#039;s Brain
Explosive thoughts
Item Room, Golden Chest

When the player shoots, they will propel a green brain in the same direction they are shooting, whether they intend to or not. The brain explodes on contact with enemies, dealing between 67.5 and 69.5 damage; if Isaac is in range of the explosion, he will also take damage. Damage increases with bomb upgrades as well as BFF. The brain will respawn shortly after exploding.

Bob's Curse Bob&#039;s Curse
Poison bombs
Item Room

Poison bombs; the player's bombs will poison enemies that are damaged by the explosion. Grants 5 bombs.

Bobby-Bomb Bobby Bomb
Friends till the end
Item Room

Homing bombs; the player's bombs now move toward enemies when placed. Grants 5 bombs.

The Body Body
I feel all
Item Room, Angel Room

Gives the player three pre-filled Red Heart Containers.

BOGO Bombs Bogo Bombs
1+1 bombs
Shop

Normal bomb pickups are now 1+1 Free bomb pickups.

Bomb Bag Bomb Bag
Gives bombs
Item Room, Secret Room

A dropping familiar that spawns a bomb pickup every 2 rooms.

Boom! Boom
10 bombs
Item Room

Gives the player 10 bombs.

Box Box
Stuff
Boss Room; Challenge Room

Spawns a random heart pickup, a bomb pickup, a coin pickup, a card, a pill, and a trinket.

Breakfast Breakfast
HP up
Boss Room; Challenge Room; Beggar

Gives the player one Red Heart Container.

Brimstone Brimstone
Blood laser barrage
Devil Room

The player now charges and shoots a laser with unlimited range and the ability to pierce obstacles and enemies. Enemies can be hit up to 13 times when firing one laser. Tip: For best results, use with either Tammy's Head, Mutant Spider, or The Inner Eye.

Broken Watch Broken watch
I think its broken
Shop

When the player enters a room, there is a chance that the enemies and music will either speed up or slow down. This can either be very useful or harmful during boss battles.

Brother Bobby Brother Bobby
Friends 'till the end
Item Room; Devil Room

Familiar that follows the player, shooting tears that deal 3.5 damage to enemies.

Bucket of Lard Bucket of Lard
HP up
Item Room

Gives the player two Red Heart Containers. Lowers the player's Speed stat by 0.2. Only a half of a heart of the two added Red Heart Containers is pre-filled.

Bum Friend Bum Friend
He's Greedy
Item Room

Familiar that follows the player, picking up nearby currency. Has a random chance to drop pickups after taking a coin.

Butt Bombs Butt Bombs
Toxic blast +5 bombs
Item Room

Bombs are now poop bombs that deal 10 damage to all enemies, as well as dazing them.

Caffeine Pill Caffeine Pill
Speed up + size down
Boss Room

Lowers the player's size. Adds 0.3 to the player's Speed stat. Gives the player a random pill.

Cain's Other Eye Cain&#039;s Eye
Near sighted friend
Item Room

Familiar eye that flies diagonally, bouncing off of walls and shooting tears in the same direction as the player fires theirs, dealing 3.5 damage per tear.

Cancer Cancer
HP up + you feel protected
Item Room

Gives the player three Soul Hearts. After taking damage once, the player can only take half a heart of damage per hit for the duration of the room.

Capricorn Capricorn
All stats up
Item Room

Gives the player one Red Heart Container and adds 1.5 to the player's Range stat, 0.15 to the player's Tears stat, 0.1 to the player's Speed stat, and 0.5 to the player's Damage stat. Also gives the player one Key, one Bomb, and one Coin.

Cat-O-Nine-Tails Cat O Nine Tails
Shot speed up + DMG up
Boss Room

Raises the player's damage by 1.0. Raises the players Shot Speed stat by 0.23.

Celtic Cross Celtic Cross
You feel blessed
Item Room; Angel Room

When the player takes damage, they have a chance to become invulnerable for a few seconds. This chance is affected by the player's Luck stat.

Ceremonial Robes Ceremonial Robes
Sin up
Devil Room; Curse Room; Demon Beggar

Gives the player three Black Hearts and increases their damage by 1.0.

Champion Belt Champion Belt
DMG + Challenge up
Shop

Increases both the player's damage and the chance of encountering Champion enemies.

Charm of the Vampire Charm of the Vampire
Kills heal
Item Room

After killing a few enemies, Isaac regenerates a half heart of red health.

Chemical Peel Chemical Peel
DMG up
Item Room

The player's Damage stat for their left eye is raised by 2.0. If the player only has one source of tears, each shot has a 50% chance to have this raise applied.

Chocolate Milk Chocolate Milk
Charge shots
Item Room

The player can now charge shots for a maximum of 4x damage. Also counts as a tears up if the player mashes the arrow key instead of holding it down.

The Common Cold Common Cold
Poison damage
Item Room

Tears now have a chance to poison enemies, causing between 4 and 6 damage per tick. This chance is affected by the player's Luck stat.

The Compass Compass
The end is near
Shop; Beggar

All icons on the map are displayed if Curse of the Blind is not present.

Contract From Below Contract From Below
Wealth, but at what cost?
Devil Room; Curse Room; Demon Beggar

Doubles the player's pickup drops. This includes consumables and chests. Chance of encountering a Double Trouble boss room is higher.

Cricket's Body Cricket&#039;s Body
Splash damage + tears up
Item Room; Golden Chest

Adds 0.16 to the player's Tears stat and removes 10.0 from the player's Range stat. Tears now split into four smaller tears on impact, small tears dealing half of the player's damage.

Cricket's Head Cricket&#039;s Head
DMG up
Item Room; Golden Chest

Adds 0.5 to the player's Damage stat and multiplies the player's Damage stat by 1.5. Tears now deal knockback.

Cube of Meat Cube of Meat
Gotta meat em all
Horsemen

Cube of Meat advances through four stages, which are as follows:
1. An orbiting familiar that blocks shots and deals contact damage.
2. An orbiting familiar that blocks shot, deals contact damage, and fires tears.
3. A free-roaming familiar that deals contact damage to the enemies that it chases.
4. A free-roaming familiar that deals more contact damage to the enemies that it chases.

Cupid's Arrow Cupid&#039;s Arrow
Piercing shots
Item Room; Golden Chest

Gives Isaac piercing tears.

Cursed Eye Cursed Eye
Cursed charged shot
Item Room; Secret Room

Tears are now charged to shoot a maximum of 4 tears at once. When the eye is black, if the player takes damage, they will be teleported to a random room.

Daddy Long legs Daddy Long Legs
Daddy's love
Item Room

Familiar that stomps on enemies randomly, dealing 40 damage.

Dark Bum Dark Bum
He wants to take your life
Item Room; Devil Room

Familiar that follows the player and picks up red hearts, giving the player spiders and Soul Hearts after pickup up a 1.5.

Dark Matter Dark Matter
Fear shot
Devil Room

Tears can apply the fear affect on enemies. Adds 1.0 to the player's Damage stat. Chance to apply fear is based on the player's Luck stat.

Dead Bird Dead Bird
Protective buddy
Item Room

After taking damage, a familiar spawns that deals contact damage to the enemies it chases for the duration of the current room.

Dead Cat Dead Cat
9 lives
Devil Room; Curse Room; Red Chest; Super Pride

The player's health is set to one Red Heart Container, but the player also gains 8 lives. When the player dies, they will respawn with only one Red Heart Container.

Dead Dove Dead Dove
Flight + spectral tears
Angel Room

Gives the player spectral tears and the ability to fly.

Dead Onion Dead Onion
Toxic aura tears
Item Room

The player's tears become larger, spectral, and piercing. Removes 0.25 from the player's range stat, 0.4 from the player's shot speed stat, and 0.5 from the player's tear height stat.

Death's Touch Death&#039;s Touch
Penetrative shots + DMG up
Devil Room; Item Room

Adds 1.5 to the player's damage stat and removes 0.3 from the player's tears stat. The player's tears are now large, piercing, scythes.

Demon Baby Demon Baby
Auto-turret friend
Devil Room; Item Room

Familiar that follows the player, automatically shoots at enemies, dealing 3 damage.

Dessert Dessert
HP up
Boss Room

Gives the player one Red Heart Container.

Dinner Dinner
HP up
Boss Room

Gives the player one Red Heart Container.

Distant Admiration Distant Admiration
Attack fly
Item Room

An orbiting fly that deals contact damage. Of the fly orbitals, Distant Admiration revolves the farthest from Isaac.

Dollar Dollar
$$$
Slot Machine

Gives the player 99 cents.

Dr Fetus Dr Fetus
???
Item Room

The player now shoots bombs that deal 3x the player's damage stat. Multiples the player's tear delay by 2.5. Poison bomb effects give the bombs 50 damage.

Dry Baby Dry Baby
Immortal friend
Item Room; Skull

Familiar that follows the player and blocks shots. When blocking shots, it has a chance to activate the Necronomicon effect.

E. Coli Ecoli
Turdy touch
Item Room

When Monsters touch the player, they turn into Poop. If the player has Midas Touch, the Monsters turn into Golden Poop.

Epic Fetus Epic Fetus
On-demand air-strike
Secret Room

Tears are now missiles that deal 20x the player's damage stat. The player now controls a red target in which a missile will fall and explode on the target after a short period of time.

Eve's Mascara Eve&#039;s Mascara
Shot speed down + DMG up
Item Room

Multiplies the player's damage stat by 2. Multiplies the player's tear delay by 2. Reduces the player's shot speed stat by 0.5.

Experimental Treatment Experimental Treatment
All stats up! ... and then shuffled
Item Room; Boss Room

Either increases or decreases each of the player's stats by a random amount.

Fanny Pack Fanny Pack
Filled with goodies
Shop, Beggar

Upon getting hit, the character may drop a consumable (Coins, Bombs, Keys, Red Hearts, Soul Hearts, etc.).

Fate Fate
Flight eternal
Golden Chest

Grants Isaac flight and an Eternal Heart.

Fire Mind Fire Mind
Flaming tears
Item Room

Gives Isaac flaming tears that set enemies on fire, and may sometimes explode on contact, this explosion chance depending on the player's Luck stat. Explosions result in lasting flames along the ground, which damages enemies. The explosions also damage Isaac if he is in range.

Forever Alone Forever Alone
Attack fly
Item Room

An orbiting fly that deals contact damage.

Gemini Gemini
Conjoined friend
Item Room

Familiar version of Gemini's Suture that is tethered to Isaac, seeking out nearby enemies to lock on and deal contact damage.

Ghost Baby Ghost Baby
Spectral buddy
Item Room; Skull; Devil Room

Familiar that shoots spectral tears.

Gimpy Gimpy
Sweet suffering
Devil Room; Curse Room

Chance to drop Soul Hearts or Black Hearts upon taking damage, which is affected by the player's Luck stat. Enemies may also drop a half heart upon death.

Gnawed Leaf Gnawed Leaf
Unbreakable
Item Room

Isaac becomes invincible when standing still. Moving at all, including shooting tears, will cancel the effect.

Goat Head Goat Head
He accepts your offering
Devil Room; Curse Room; Golden Chest; Red Chest

Guarantees a Devil or Angel Room on every floor, and keeps the door to these rooms open indefinitely even after leaving. Angel rooms are now less commonly encountered.

Godhead God Head
God tears
Angel Room

Isaac's tears now have a homing effect with a large aura, this aura dealing contact damage. Adds 0.5 to the player's damage stat, 0.8 to the player's tear height stat, and 1.2 to the player's range sat. Also removes 0.2 from the player's tears stat and 0.3 from the player's shoot speed stat.

Growth Hormones Growth Hormones
DMG up + speed up
Boss Room

Adds 1.0 to the player's damage stat and 0.4 to the player's speed stat.

Guardian Angel Guardian Angel
Extra protection
Angel Room

Orbital that deals contact damage and revolves around Isaac at an increased speed. Any other orbitals will also gain this speed increase. Also blocks shots.

Guillotine Guillotine
An out-of-body experience
Item Room

Increases the player's damage stat by 1.0 and the player's tears stat by 0.16. Isaac's head is now an orbiting familiar that shoots and blocks shots. This head cannot take damage.

Guppy's Collar Guppy&#039;s Collar
Eternal life?
Devil Room; Curse Room; Red Chest

One of five Guppy items; grants Isaac a 50% chance to respawn at 1/2 heart upon death, indefinitely. Upon respawning, Isaac will only have one Red Heart Container.

Guppy's Hairball Guppy&#039;s Hairball
Swing it
Devil Room

One of five Guppy items; a familiar that trails behind Isaac and can be swung around using Isaac's momentum to deal contact damage. It grows in size and damage as it kills enemies, and resets at the start of each floor.

Guppy's Tail Guppy&#039;s Tail
Cursed?
Devil Room; Curse Room; Red Chest

One of five Guppy items; greatly increases the chance of chest-type drops, but decreases the chance for consumable drops like keys and bombs.

Habit Habit
Item martyr
Shop; Angel Room

Refills a tick of charge to the player's Active Item upon taking damage.

Halo  Halo
All stats up
Item Room; Boss Room; Angel Room

Adds 0.3 to the player's damage stat, 0.2 to the player's tears stat, 0.25 to the player's range stat, 0.3 to the player's speed stat, and 0.5 to the player's tear height stat. Also gives Isaac a Red Heart Container.

Halo of Flies Halo of Flies
Projectile protection
Item Room

Dual close-range fly orbitals that block tears.

Harlequin Baby Harlequin Baby
Double shot buddy
Item Room

Familiar that shoots tears two at a time in a V-pattern.

Headless Baby Headless Baby
Bloody friend
Item Room; Devil Room

Familiar that tracks creep in the form of blood behind it, the familiar following Isaac.

Hive Mind Hive Mind
Giants spiders and flies
Shop

Increases the size and doubles the damage of friendly flies and spiders. Mom's Wig can now spawn up to 10 spiders instead of the original 5.

Holy Grail Holy Grail
Flight + HP up
Angel Room

Grants flight as well as one heath up.

Holy Mantle Holy Mantle
Holy shield
Item Room; Angel Room

Allows Isaac to absorb one hit per room without taking any damage. This also works to enter/exit Curse Rooms for free. That is, of course, if Isaac has not previously taken damage in the room before the Curse Room or the Curse Room itself.

Holy Water Holy Water
Splash!
Itme Room; Angel Room

Upon taking damage, the bottle breaks and leaves a pool of water on the ground which acts as creep, dealing contact damage to enemies that walk over it.

Hot Bombs Hot Bombs
Burning blast +5 bombs
Item Room

Adds a fire effect to bombs, causing flames to spread along the floor upon exploding. Gives Isaac 5 Bombs.

Humbling Bundle Humbling Bundle
1+1free 4evar!
Shop

Consumables and Pickups will drop in pairs. Soul Hearts, Eternal Hearts, Black Hearts, Nickels, Dimes, Cards, and Pills are unaffected.

Infamy Infamy
Damage reduction
Item Room; Secret Room; Golden Chest

Chance that Isaac will not take damage when hit.

Infestation Infestation
They grow inside
Item Room

Causes friendly Blue Flies to spawn when Isaac takes damage.

Infestation 2 Infestation 2
Infestation shot
Item Room

Chance to spawn friendly Blue Spiders when Isaac kills an enemy.

The Inner Eye Inner Eye
Triple shot
Item Room

Triple-shot, as well as a significant tears down.

IPECAC Ipecac
Explosive shots
Item Room

Explosive tears that shoot in an arc over the room and inflict poison damage.

Iron Bar Iron Bar
Concussive tears
Item Room

Tear effect that may cause enemies to become dazed on hit.

Isaac's Heart Isaac&#039;s Heart
Protect it
Item Room

Isaac becomes invincible, but is followed by a heart familiar that, when hit, transfers the damage taken by it to Isaac.

Jesus Juice Jesus Juice
Damage + range up
Boss Room

Isaac's stats are improved, his Damage stat increased by 0.5, his Range stat increased by 0.25, and his Tear Height stat increased by 0.5.

Judas' Shadow Judas&#039; Shadow
Sweet revenge
Item Room; Devil Room

When Isaac is killed, he will respawn as Judas' Shadow in the previous room, this character having 2 Black Heart Containers as health. Upon death, Isaac's base damage is set to 7.

Juicy Sack Juicy Sack
Sticky babies
Item Room

Familiar that follows Isaac, leaving slowing creep behind. Will occasionally spawn a blue spider upon finishing a room.

Key Piece #1 Key Piece 1
???
Angel Boss

Increases the player's chance of finding an Angel Room. The first half of the key needed to reach Mega Satan.

Key Piece #2 Key Piece 2
???
Angel Boss

Increases the player's chance of finding an Angel Room. The second half of the key needed to reach Mega Satan.

The Ladder Ladder
Building bridges
Shop

Isaac can now walk over holes with widths of one tile.

Lazarus' Rags Lazarus&#039;s Rags
Eternal life?
Item Room; Angel Room

Gives Isaac an extra life. Upon respawning, Isaac will have 1 Red Heart Container and Anemic. Isaac is now considered Lazarus II.

Leo Leo
Stompy
Item Room

Isaac can now crush rocks and poop by touching them. Crushed rocks and poop can fill holes depending on the direction in which Isaac is walking.

Latch Key Latch Key
Luck up
Boss Room

Isaac receives one Soul Heart and his Luck stat is boosted by 1. 2 keys are spawned.

Leech Leech (Item)
Blood sucker
Item Room

Familiar that charges at enemies and deals contact damage. Upon killing an enemy, Leech will restore half of one of Isaac's Red Heart Containers.

Libra Libra
You feel balanced
Item Room

Isaac gains six of every consumable (excluding Pills and Tarot Cards). The following stat changes for Libra only affect Isaac's Damage, Range, Speed, and Tears stats. Libra attempts to average out Isaac's stats (low stats are brought up and high stats are brought down). Future stat ups are made into very minute all stats up.

Lil' Brimstone Lil Brimstone
Evil friend
Item Room; Devil Room

A familiar that shoots Brimstone lasers that deal 31.5 damage.

Lil' Haunt Lil Haunt
Fear him
Item Room

A familiar that charges at enemies when close and deals contact damage. It has a chance to induce a Fear effect on contact.

Little Baggy Little Baggy
Extra pill room
Shop

Isaac is given an extra slot to hold a Pill. Upon picking Little Baggy up, a Pill spawns. All Tarot Card drops are now Pill drops.

Little C.H.A.D. Little Chad
Gives kisses
Item Room; C.H.A.D.

A familiar that drops a Half Red Heart upon Isaac clearing three Rooms.

Little Chubby Little Chubby
Attack buddy
Item Room

A familiar that charges in the direction that Isaac is shooting, dealing contact damage to Enemies.

Little Gish Little Gish
Stick friend
Item Room; Gish

A familiar that shoots tears that have a chance to give Enemies a Slow effect. Little Gish's tears to 3.5 damage.

Little Steven Little Steve
Psychic friend
Item Room; Boss Room

A familiar that shoots homing tears that do 3.5 damage.

Loki's Horns Loki&#039;s Horns
Cross tears
Item Room

When Isaac fires a tear, there is a chance that he will shoot a tear in each of the four cardinal directions. At 7 Luck, Isaac will do a four-way shot every time.

Lord of the Pit Lord of the Pit
Demon wings
Devil Room

Gives Isaac flight and adds 0.3 to the next Speed up.

Lost Contact Lost Contact
Shielded tears
Item Room; Secret Room

Isaac's tears now have a shield around them, now allowing them to destroy projectiles. Upon destroying a projectile, however, the tear will also be destroyed. Lost Contact also removes 0.15 from Isaac's Shot Speed stat.

Lucky Foot Lucky Foot
Luck up
Item Room; Beggar

Isaac's Luck stat is increased by 1.0.

The Ludovico Technique Ludovico Technique
Controlled tears
Item Room

Isaac now has a single tear that the player controls using the arrow keys. The Tears stat now affects how fast damage is inflicted by the tear. The Shot Speed stat now affects how fast the tear moves.

A Lump of Coal Lump of Coal
My Xmas present
Krampus

Isaac's Damage stat is increased. The further a tear is from Isaac, the more damage it deals.

Lunch Lunch
HP up
Beggar; Boss Room; Challenge Room

Isaac gains a full Red Heart Container.

Maggy's Bow Maggy&#039;s Bow
HP up + you feel healthy
Item Room

Isaac gains a full Red Heart Container. Red Heart Pickups now heal twice as much as normal.

Magic 8 Ball Magic 8 Ball
Shot speed up
Boss Room

Isaac's Shot Speed stat is increased by 0.16. A random Tarot Card is placed in Isaac's inventory.

Magic Mushroom Magic Mushroom
All stats up!
Boss Room; Item Room; Mushrooms (Destructible Stage 2 Props)

Isaac gains a full Red Heart Container and his size is increased. It also adds 0.3 to Isaac's Damage stat, 5.25 to Isaac's Range stat, 0.3 to Isaac's Speed stat, and 0.5 to Isaac's Tear Height stat (to compensate for the size change). Magic Mushroom also refills all of Isaac's Red Heart Containers.

Magic Scab Magic Scab
HP + luck up
Boss Room

Isaac gains a full Red Heart Container and his Luck stat is increased by 1.0.

Magneto Magneto
Item snatcher
Item Room

Pickups and Consumables are now attracted to the player.

The Mark Mark
Damage Up
Curse Room; Devil Room

Isaac's Damage stat is increased by 1.0 and his Speed stat is increased by 0.2. Isaac also gains one full Soul Heart Container.

Match Book Matchbook
Evil up
Boss Room

Isaac is given a full Black Heart Container and 3 Bombs.

Meat! Meat
DMG + HP up
Boss Room

Isaac is given one full Red Heart Container and his Damage stat is increased by 0.3.

Midas Touch Midas
Golden touch
Item Room

Isaac temporarily turns enemies into gold on contact, thus freezing them for a short amount of time. If the enemy is killed during this time, they will drop between 1-4 random Coins. Contact damage that is weighed depending on how many Coins Isaac has is also dealt.

The Mind Mind
I know all
Angel Room; Item Room

All rooms are revealed and mapped.

Mini Mush Mini Mushroom
Speed + range up
Item Room; Mushrooms (Destructible Stage 2 Props)

Isaac's Speed stat is increased by 0.3. He also decreases in size. Isaac's Range stat is decreased by -4.25, but this ultimately ends up being a Range increase when paired along with the fact that Mini Mush also increases his tear height by 1.5.

Missing No. Missingno
Syntax error
Secret Room

Upon starting a new Floor, all of Isaac's Collectibles are re-rolled.

Missing Page 2 Missing Page 2
Evil up + your enemies will pay
Demon Beggar; Devil Room; Secret Room

Isaac gains one full Black Heart Container. Upon taking damage, if the sum of Isaac's Soul Hearts and Red Hearts are less than 1.5, all enemies in the Room will receive 40 damage.

Mitre Mitre
You feel blessed
Angel Room; Item Room

Isaac's chance to find Soul Hearts is greatly increased.

Mom's Coin Purse Mom&#039;s Coin Purse
What's all this...?
Beggar; Boss Room; Challenge Room; Demon Beggar; Shop

4 random Pills are generated around Isaac.

Mom's Contacts Mom&#039;s Contacts
Freeze effect
Challenge Room; Item Room

Tears may now temporarily freeze enemies, the chance of this occurring depending on Isaac's Luck stat. Isaac will receive an additional 0.25 to his next Range Stat change. He will also receive an additional 0.5 to his next Tear Height change.

Mom's Eye Mom&#039;s Eye
Eye in the back of your head
Challenge Room; Item Room;

A tear may now fire from behind Isaac towards the opposite direction he is shooting when Isaac is firing, the chance of this occurring depending on his Luck stat. At 2.0 Luck, this will occur every time Isaac fires.

Mom's Eyeshadow Mom&#039;s Eye Shadow
Charm Tears
Challenge Room; Item Room

Isaac's tears may now charm enemies, the chance of this occurring depending on his Luck stat. This will always happen at 27 Luck.

Mom's Heels Mom&#039;s Heels
Range up
Boss Room; Challenge Room

Isaac's Range stat is increased by 5.25. His Tear Height stat is increased by 0.5.

Mom's Key Mom&#039;s Key
Less is more now + 2 keys
Challenge Room; Key Beggar; Shop

Isaac gains 2 Keys. Chests will now have a chance to drop even more Pickups and Consumables.

Mom's Knife Mom&#039;s Knife
Stab stab stab
Challenge Room; Devil Room; Item Room

Tears are now a knife that can either be charged and thrown (return to sender) or just used to stab close-range without having to charge. It deals twice the damage when used without charging, however.

Mom's Lipstick Mom&#039;s Lipstick
Range up
Boss Room; Challenge Room

Isaac's Range stat is increased by 5.25. His Tear Height stat is increased by 0.5.

Mom's Perfume Mom&#039;s Perfume
Fear shot
Challenge Room; Item Room

Isaac's tears have a chance to inflict a fear effect on enemies, this chance depending on his Luck stat. At 85 Luck, it will inflict fear every time. Isaac's Tear Delay stat is decreased by 1.

Mom's Purse Mom&#039;s Purse
More trinket room
Shop

Isaac is given another Trinket slot.

Mom's Wig Mom&#039;s Wig
You feel itchy
Challenge Room; Item Room

Each time he fires a tear, Isaac has a chance to spawn a friendly Attack Spider, this chance depending on Isaac's Luck stat and activating each time at 10 Luck. Only 5 Attack Spiders can be present at a time, unless Isaac has Hive Mind, which allows up to 10 Attack Spiders to be present at one time. Upon picking Mom's Wig up, one of Isaac's Red Heart Containers is refilled.

Mom's Underwear Mom&#039;s Underwear
Range up
Boss Room; Challenge Room

Isaac's Range is increased by 5.25. His Tear Height stat is increased by 0.5.

Money = Power Money is Power
$$$ = DMG
Item Room

Isaac has a DMG boost depending on how many Coins he has. A maximum of 3.96 DMG can be added (99 Coins).

Mongo Baby Mongo Baby
Mongo friend
Item Room

Spawn a Familiar that normally fires tears when Isaac fires. However, if another Familiar is present, Mongo Baby will imitate that Familiar.

Monstro's Lung Monstro&#039;s Lung
Charged attack
Item Room

Isaac now charges a barrage of tears of assorted sizes that fire upon releasing the fire button once charged enough.

Mr. Mega Mr Mega
Blast damage
Item Room; Secret Room

Isaac gains 5 bombs and his bombs now do 110 damage instead of the default 50.

The Mulligan Mulligan
They grow inside
Item Room

Isaac has a chance to spawn an Attack Fly upon one of his tears hitting an enemy. The Attack Flies do 2x Isaac's damage.

Mutant Spider Mutant Spider
Quad shot
Item Room

Isaac now shoots 4 tears at once. However, Isaac's tear delay is multiplied by 2.1 and increased by 3, significantly reducing how fast Isaac can fire tears.

My Reflection My Reflection
Boomerang tears
Item Room

Tears now return to Isaac. Isaac's Range stat is increased by 1.5, his Shot Speed stat is increased by 0.6, and his Tear Height stat is increased by 1.

Mysterious Liquid Mysterious Liquid
Toxic splash damage
Item Room

Upon impact, Isaac's tears leave a small puddle of creep.

Mystery Sack Mystery Sack
?
Beggar; Item Room; Secret Room

Spawns a familiar that follows Isaac and drops a random Pickup every couple of Rooms.

The Negative Negative
Fate Chosen
Mom

When Isaac is lowered to 1/2 a Heart Container, all enemies in the Room take 40 damage. The Negative also allows Isaac access to the Dark Room.

Number One Number One
Tears up
Item Room

Isaac now urinates, reducing his Range stat by 15.78, increasing his Tears stat by 1.5, and increasing his Tear Height stat by 0.45.

Odd Mushroom (Thick) Odd Mushroom (Large)
DMG up
Item Room; Secret Room

Gives Isaac a full Red Heart Container, increases Isaac's Damage stat by 0.3, increases Isaac's Range stat by 0.25, increases Isaac's Tear Height stat by 0.5, and decreases Isaac's Speed stat by 0.1. Isaac's head size is also increased.

Odd Mushroom (Thin) Odd Mushroom (Thin)
Fire rate up
Item Room; Secret Room

Isaac's Tears stat is increased by 1.7, his Speed stat is increased by 0.3, and his Damage stat is multiplied by 0.9 and decreased by 0.4 (multiplying by a positive number less than 1 decreases the stat).

Old Bandage Old Bandage
HP up
Boss Room

Isaac is given an empty Red Heart Container. Upon taking damage, Isaac has a chance to drop some Red Hearts.

Ouija Board Ouija Board
Spectral Tears
Item Room

Isaac's tears now travel through obstacles such as Rocks and Explosives.

The Pact Pact
DMG + tears up
Curse Room; Devil Room

Isaac's DMG stat is increased by 0.5, his Speed stat is increased by 0.7, and he gains two full Soul Heart Containers.

Pageant Boy Pageant Boy
Ultimate grand supreme
Boss Room

7 random Coins are spawned around Isaac.

The Parasite Parasite
Split shot
Item Room

Isaac's tears now split on contact with obstacles (rocks, enemies, walls, etc.). The tears that split off do 0.25 times (1/4 of) Isaac's Damage.

The Peeper Peeper
Plop!
Item Room

The Peeper is a familiar that bounces diagonally off of obstacles around the room and deals contact damage, similarly to Peep's eyes.

Pentagram Pentagram
DMG up
Boss Room; Curse Room; Devil Room

Isaac's Damage stat is increased by 1.0. The chance of a Devil Room spawning after a Boss fight is approximately 20%.

PHD PHD
Better pills
Item Room, Shop

All pills have either a neutral or positive effect and are identified upon being picked up. One pill is dropped upon picking up PHD and refills 2 Red Heart containers.

Piggy Bank Piggy Bank
My life savings
Item Room; Shop

Isaac receives three Coins and, upon taking damage, he spawns 1-2 Coins near him.

Pisces Pisces
Tears up + knockback shot
Item Room

Isaac's Tear Delay stat is decreased by 1, ultimately increasing his fire rate. It also gives Isaac's tears a knockback effect, in which tears push enemies back.

Placenta Placenta
HP up + health regen
Boss Room

Isaac gains an additional Red Heart container and health regeneration over time.

The Polaroid Polariod
Fate chosen
Mom

Upon his health being lowered to 1/2 Hearts, Isaac is protected by a temporary shield. Isaac also gains entry to The Chest.

Polyphemus Polyphemus
Mega tears
Item Room

Isaac's Damage stat is increased by 4 and then multiplied by 2.0. Isaac's Tear Delay stat is also multiplied by 2.1 and increased by 3. If a tear happens to kill an enemy, the tear continues to travel with the remaining damage, if any.

Proptosis Proptosis
Short range mega tears
Item Room

Tear damage increase depends on how long it has been after Isaac fired a tear (+100% to +30%). Isaac's tears are also bigger after being fired than when they lose momentum.

Punching Bag Punching Bag
Scape goat
Item Room

An invulnerable Mulligan spawns. Enemies will treat this Mulligan as they would treat Isaac.

Pyro Pyro
99 Bombs
Item Room; Secret Room

Isaac's Bomb count is set to 99, the maximum number of Bombs he can own.

Pyromaniac Pyromaniac
Hurts so good +5 bombs
Item Room

Explosions (including Mom/Satan's foot/leg) no longer hurt Isaac, but actually have a chance to heal him. This can be really useful with Kamikazee.

A Quarter Quarter
+25 coins
Basement Pots; Item Room; Secret Room; Super Greed

Isaac's Coin count is increased by 25 cents.

Rainbow Baby Rainbow Baby
Random Buddy
Item Room

A Familiar is spawned that shoots tears with random effects.

Raw Liver Raw Liver
HP up
Secret Room

Increases Isaac's Red Heart Container count by 2 and heals one Red Heart Container.

The Relic Relic
Soul generator
Angel Room; Item Room

Spawns a Familiar that, every 4 Rooms, spawns a Soul Heart.

Robo-Baby Robo-Baby
Frinds till the bzzzttt
Item Room

Robo-Baby is a familiar that follows Isaac, shooting piercing Technology beams that deal 3.5 damage.

Robo-Baby 2.0 Robo-Baby 2
We worked out all the kinks
Item Room

Robo-Baby 2.0 is a familiar that is controlled by the arrow keys. When alligned with an enemy, it will shoot a Technology beam that deals 3.5 damage.

Roid Rage Roid Rage
Speed and range up
Boss Room; Demon Beggar; Item Room

Isaac's Speed stat is boosted by 0.6, his Range stat by 5.25, and his Shot Height stat by 0.5.

Rosary Rosary
Faith up
Angel Room; Item Room

Isaac gains three soul hearts and The Bible is added into Item Pools several times.

Rotten Baby Rotten Baby
Infested friend
Devil Room; Item Room

Rotten Baby is a familiar that follows Isaac, releasing flies (only one is allowed on-screen) that do 2 times Isaac's damage. If Hive Mind is held, the flies will do 4 times Isaac's damage.

Rotten Meat Rotten Meat
HP up
Beggar; Boss Room; Challenge Room

Isaac gains one Red Heart Container.

Rubber Cement Rubber Cement
Bouncing tears
Item Room

Isaac's tears now bounce off of enemies, walls, and obstacles. This Item synergizes well with Lost Contact.

Sack of Pennies Sack of Pennies
Gives money
Item Room; Secret Room

A random Coin drops for ever 2 Rooms completed.

Sacred Heart Sacred Heart
Homing shots + DMG up
Angel Room

Tears are homing and slower. Isaac's Tear Height stat is increased by 0.75, his Range stat by 0.375, and his Damage stat is multiplied by 2.3 with an additional boost of 1. His Tears stat is lessened by 0.4 and his Shot Speed stat is lessened by 0.25. Isaac gains a Red Heart Container and all of his Red Heart Containers are restored (filled).

Sacrificial Dagger Sacrificial Dagger
My fate protects me
Devil Room; Item Room

Sacrificial Dagger is an orbital Familiar (a Familiar that orbits around Isaac, blocking shots and dealing contact damage). It specifically does 15 damage per tick, around 3 times Isaac's base damage.

Sad Bombs Sad Bombs
Tear blast +5 bombs
Item Room

Bombs now shoot out tears in an asterisk pattern upon exploding, being larger and dealing much more damage than Isaac's current tears. Isaac also gains 5 Bombs.

The Sad Onion Sad Onion
Tears up
Item Room

Isaac's Tears stat is boosted by 0.7.

Safety Pin Safety Pin
Evil up + range + shot speed
Boss Room

Isaac's Tear Height stat is boosted by 0.5, his Range stat by 5.25, his Shot Speed stat by 0.16. Isaac also gains a Black Heart Container.

Sagittarius Sagittarius
Penetrative shot + speed up
Item Room

Isaac's Speed stat is boosted by 0.2 and his tears now pierce through multiple enemies.

Samson's Chains Samson&#039;s Chains
The ol' ball and chain
Item Room; Secret Room

Isaac gains a chain familiar that damages enemies and breaks Rocks when moving fast enough. It can also block shots.

Scapular Scapular
You have been blessed
Angel Room; Item Room

When Isaac takes damage that brings him down to one half of a Red Heart, he will be given a Soul Heart container. This effect can only happen once per room.

Scorpio Scorpio
Poison tears
Item Room

Isaac's tears now apply a poison effect, doing 4-6 damage per tick.

Screw Screw
Tears + shot speed up
Boss Room

Isaac's Tears stat is boosted by 0.5 and his Shot Speed stat is boosted by 0.2.

Sharp Plug Sharp Plug
Charge with blood
Shop

Isaac will be able to use his Active Item when it is not fully charged at the cost of a full Heart container.

Sissy Long Legs Sissy Long Legs
She loves you
Item Room

Sissy Long Legs is a spawning familiar that will occasionally spawn friendly Spiders that deal 2.5 times Isaac's current Damage.

Sister Maggy Sister Maggy
Friends 'till the end
Devil Room; Item Room

Sister Maggy is a following familiar that shoots tears that deal 3.5 damage.

Skatole Skatole
Fly lover
Shell Game Beggar

Attack flies will now be Black Flies and Black Flies will now fly towards Isaac's head. Pooters and Super Pooters will be passive while Boom Flies and Red Boom Flies will fly slower.

Skeleton Key Skeleton Key
99 keys
Secret Room;

Isaac is given 99 Keys.

The Small Rock Small Rock
DMG up
Tinted Rock

Isaac's Damage stat is boosted by 1 and his Tears stat is boosted by 0.2. It will also drop Isaac's Speed stat by 0.2.

Smart Fly Smart Fly
Revenge fly
Item Room; Key Beggar

Smart Fly is originally an orbiting Familiar. However, when Isaac takes damage, Smart Fly will chase and attack enemies. If no enemies are near, it will return to orbiting, only to attack once again if an enemy nears. This effect is recent upon entering another room.

SMB Super Fan SMB Super Fan
All stats up
Item Room

Isaac will turn into Meat Boy and receive a 0.3 Damage up, a 0.2 Speed up, a 0.5 Range up, a 1.0 Tear Height up, and a 0.2 Tears up. Isaac will also receive one Red Heart container and all of his Red Hearts will be restored.

A Snack Snack
HP up
Boss Room

Isaac gains a Red Heart container.

The Soul Soul
I am all
Item Room, Angel Room

Isaac gains 2 Soul Hearts. Also, enemy tears now slowly move away from Isaac.

Soy Milk Soy Milk
DMG down + tears way up
Item Room

Isaac's tear delay is divided by 4 and subtracted by 2, giving him an insane firing rate. Isaac's damage is reduced by 80%, an insane Damage down.

Speed Ball Speedball
Speed + shot speed up
Boss Room; Demon Beggar; Item Room

Isaac's Shot Speed stat is boosted by 0.2 and Isaac's Speed stat is boosted by 0.3.

Spelunker Hat Spelunker Hat
See-through doors
Item Room

Secret Room locations are revealed on the mini-map when in a room touching them.

Spider Bite Spider Bite
Slow effect
Item Room

Tears can now slow enemies for 2.5 seconds. The chance is affected by Isaac's Luck stat, 15 activating the effect every time.

Spiderbaby Spider Baby
Spider revenge
Item Room

Isaac releases a friendly Spider upon taking damage.

Spirit of the Night Spirit of the Night
Scary
Devil Room

Isaac can now fly and has spectral tears (tears that go through obstacles, not including enemies).

Spoon Bender Spoonbender
Homing shots
Item Room

Isaac's tears now have a homing effect, slowly homing in on enemies.

Squeezy Squeezy
Tears up
Boss Room

Isaac's Tear stat is boosted by 0.4 and he is given 2 Soul Hearts.

Starter Deck Starter Deck
Extra card room
Shop

Isaac can now hold two Cards. All Pill spawns are replaced with Cards.

Steam Sale Steam Sale
50% off
Greed; Shop; Shopkeeper

Shop items are now 50% off.

Stem Cells Stem Cells
HP up
Boss Room; Item Room

Isaac's Shot Speed stat is boosted by 0.16 and he gains one Red Heart container.

Steven Steven
DMG up
Steven

Isaac's Damage stat is boosted by 1.

Stigmata Stigmata
DMG + HP up
Item Room

Isaac's Damage stat is boosted by 0.3 and he gains one Red Heart container.

Stop Watch Stop Watch
Let's slow this down a bit
Shop

Isaac gains a Speed stat increase of 0.3. Also, all enemies and tears are slowed down.

Strange Attractor Strange Attractor
Magnetic tears
Item Room

Enemies and pickups are now attracted to Isaac's tears.

Super Bandage Super Bandage
+2 hearts
Boss Room; Item Room

Isaac gains a Red Heart container and 2 Soul Hearts.

Synthoil Synthoil
DMG up + range
Boss Room

Isaac's Damage stat is boosted by 1, his Range stat by 5.25, and his Tear Height by stat 0.5.

Taurus Taurus
Speed down + rage is building
Item Room

Isaac's Speed stat is reduced by 0.3. While in a room with enemies, Isaac's speed stat will increase by 0.065 per second. Once the speed hits 2.0, Isaac will gain the My Little Unicorn effect, allowing him invincibility, increased speed, and contact damage (40 damage per tick) for a time.

Active Items

Active items are "use items" that take up an item slot. Because the use command is bound by default to the spacebar, they are also often called Spacebar Items. These items require a charge to use, and have a variety of effects ranging from stat increases, room or floor effects, special attacks, health recovery, and much more.

Item Icon Item Pool Effect Charge
Anarchist's Cookbook Anarchist Cookbook  Item Room; Library Spawns troll bombs randomly around the room. Isaac can also be damaged by these, and because they spawn one after the other, they do not explode simultaneously and as a result can easily bounce each other around the room. Three rooms
The Bean Bean  Item Room Causes Isaac to fart, emitting a close-range green cloud that damages and poisons enemies that come into contact with it. One room
Best Friend Best Friend  Item Room Places a decoy Isaac on the floor which attracts enemies, then explodes with the same power as a Mr. Mega bomb. Can be used as a regular bomb should the player need one in a pinch. Three rooms
Blank Card Blank Card  Shop; Item Room; Secret Room Activates the player's held tarot or playing card without consuming the card. Also works with runes. Four rooms
Blood Rights Blood Rights  Item Room Sacrifices a Red Heart to deal mass damage to the room.  None
Bob's Rotten Head Bob&#039;s Rotten Head  Item Room; Golden Chests Throws a poison bomb in the direction Isaac is facing.  Three rooms
Book of Revelations Book of Revelations  Item Room; Library Grants Isaac one Soul Heart and guarantees a Horseman boss fight, if possible. Six rooms
Book of Secrets Book of Secrets  Item Room; Secret Room, Library Reveals either the full map (Treasure Map effect), secret and top secret room locations (Blue Map effect), or special room locations (Compass effect). Six rooms
Book of Shadows Book of Shadows  Item Room; Library Grants the player temporary invincibility. Three rooms
Book of Sin Book of Sin  Item Room; Devil Room; Library Drops a random pickup. Four rooms
Boomerang Boomerang  Shop x Slowly recharges immediately after use
Box of Spiders Box of Spiders  Item Room Spawns 2-4 blue spiders. Two rooms
Breath of Life Breath of Life  Angel Room Holding the spacebar causes the charge to drain, granting Isaac invincibility when it reaches zero. Holding it for too long afterward will cause Isaac to take damage.  Gradually recharges after use.
Butter Bean Butter Bean  Item Room, Beggar Knocks back any enemy within a close-range radius of Isaac. Gradually recharges after use.
The Candle Blue Candle  Shop Launches a powerful blue flame across the floor, burning any enemy in its path. Gradually recharges after use.
Converter Converter  Shop Instantly converts two Soul or Black Hearts into one Red Heart Container. None
Crack the Sky Crack the Sky  Item Room Summons damaging beams of white light from the sky, which touch down in a random pattern.  Four rooms
Crystal Ball Crystal Ball  Item Room; Fortune Teller Machines Reveals the full map (Treasure Map, Blue Map, and Compass effects), and drops a Soul Heart, Tarot Card, or Rune. Six rooms
D4 D4  Item Room Rerolls the player's entire item set. Six rooms
D10 D10  Item Room Rerolls all of the enemies in the room. One room
D20 D20  Item Room Rerolls pickups and consumables in the room, including hearts of any type, coins, bombs, keys, cards, pills, trinkets, and chests. Six rooms
D100 D100  Item Room Combined effects of the D4, D6, and D20.  Six rooms
Dad's Key Dad&#039;s Key  Item Room; Key Beggar Unlocks and opens all doors attached to a room, including secret and top secret rooms, Boos Room doors, Challenge and Boss Challenge Rooms, and the Golden Door in The Chest/Dark Room. Two rooms
Dead Sea Scrolls Dead Sea Scrolls  Item Room; Angel Room Random Active Item effect. Four rooms
Deck of Cards Deck of Cards  Shop; Item Room Drops a tarot or playing card. Six rooms
Doctor's Remote Doctor&#039;s Remote  Item Room Summons a missile from above, aimed via a red crosshair on the floor.  Three rooms
Flush! Flush  Item Room Turns all enemies in a room into poop. Touching the poop can still hurt Isaac, but otherwise it's just poop. Does not work on bosses or minibosses. Six rooms
Forget Me Now Forget Me Now  Item Room; Secret Room Immediately starts the floor over, re-randomized into a brand-new floor. Once used, the Forget Me Now disappears. Instant; one use only
The Gamekid Game Kid  Item Room Grants temporary invincibility, contact damage, and health regeneration per enemy killed while in this state. Six rooms
Guppy's Head Guppy&#039;s Head  Devil Room; Curse Room; Golden Chests; Red Chests One of five Guppy items; spawns 2-4 blue flies on each use. Flies can continue being spawned indefinitely, and carry over between rooms. One room
Guppy's Paw Guppy&#039;s Paw  Devil Room; Curse Room; Red Chests One of five Guppy items; immediately converts a Red Heart Container into three Soul Hearts. None
Head of Krampus Head of Krampus  Drops from Krampus Four-directional Brimstone shot. Six rooms
The Hourglass Hour Glass  Item Room Slows all enemies in the room. Two rooms
How To Jump How to Jump  Item Room; Library Allows Isaac to jump over gaps, rocks, spikes, and other obstacles. None
Isaac's Tears Isaac&#039;s Tears  Item Room Eight-directional tear shot that gets recharged as Isaac continues to shoot. Recharges one tick per shot fired

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