Consumables

Consumables are similar to Pickups, but they take up the Consumable slot and are used by pressing Q.

Cards

Card Consumables consist of Playing Cards and Tarot Cards.

Name	Image	Effect
O - The Fool	Where your journey begins	Isaac is teleported back to the starting Room.
I - The Magician	May you never miss your goal	Isaac's tears will now have a homing effect.
II - The High Priestess	Mother is watching you	Mom's foot stomps on an enemy. If no enemies are present, she will stomp on Isaac.
III - The Empress	May your rage bring power	Isaac will gain a Whore of Babylon effect for the current Room, increasing his Damage and Speed stats.
IV - The Emperor	Challenge me!	Isaac will be teleported to the Boss Room.
V - The Hierophant	Two prayers for the lost	Two Soul Hearts will spawn beside Isaac.
VI - The Lover	May you prosper and be in good health	Two Red Hearts will spawn beside Isaac.
VII - The Chariot	May nothing stand before you	Isaac will gain a My Little Unicorn effect, causing him to do contact damage and gain a large Speed boost.
VIII - Justice	May your future become balanced	A bomb, a heart, a coin, and a key will spawn beside Isaac.
IX - The Hermit	May you see what life has to offer	Isaac will be teleported to the Shop Room.
X - Wheel of Fortune	Spin the wheel of desiny	A Slot Machine or Fortune Telling Machine will spawn near Isaac.
XI - Strength	May your power bring rage	Isaac's stats and size are increased for the current Room. It will also increase his health by one Red Heart Container.
XII - The Hanged Man	May you find enlightenment	Isaac gains flight.
XIII - Death	Lay waste to all the oppose you	All enemies take 40 damage.
XIV - Temperance	May you be pure in heart	A Blood Donation Machine spawns beside Isaac.
XV - The Devil	Revel in the power of your darkness	Isaac's Damage is increased for the current Room.
XVI - The Tower	Destruction brings creation	Several troll bombs spawn randomly around the room.
XVII - The Stars	May you find what you desire	Isaac is teleported to the Item Room.
XVIII - The Moon	May you find all you have lost	Isaac is teleported to the Secret Room.
XIX - The Sun	May the light heal and enlighten you	Isaac is completely healed. All enemies take 40 damage. All rooms are revealed.
XX - Judgement	Judge lest ye be judged	A Beggar, Demon Beggar, or Key Beggar will spawn near Isaac.
XXI - The World	Open your eyes and see	All rooms are uncovered on the map.
2 of Spades	Item Multiplier	Isaac's keys are doubled. If he has no keys, he gains two.
2 of Clubs	Item Multiplier	Isaac's bombs are doubled. If he has no bombs, he gains two.
2 of Hearts	Item Multiplier	Isaac's Red Heart count is doubled (NOT Containers). If he only has half a heart, he heals for two Red Hearts.
2 of Diamonds	Item Multiplier	Isaac's coins are doubled. If he has no coins, he gains two.
Joker	???	Isaac is teleported to either the Angel Room or the Devil Room.
Chaos Card	???	Isaac throws a card that opens doors and destroys obstacles. It also kills any enemy in one hit.
Credit Card	Charge it!	If used in a shop, all items in the shop are bought for free. If used in a Devil Room, all items there are free.
Rules Card	???	A random hint is displayed. The hints that can be displayed are as follows: Rooms may yield more than you expect. Experimentation is key. Some doors require a blessing. Carry them with you. The walls will harden over time. Time is the essence. Sleeping gatekeepers will need to be awoken with a loud sound. A piece of paper is your guide. Deny his gifts to retain your award. A dark market lies under your feet. Chub dislikes smoke!
Card Against Humanity	Something stinks...	The entire room is filled with poop.
Suicide King	A true ending?	Isaac dies and 10 Pickups spawn. Three of these Pickups can be Collectibles. The Collectibles will be from the current Room's Item Pool.
Get Out of Jail Free Card	Open sesame	When used, all doors in the Room will open.
? Card	Double active	Isaac's Active Collectible is used once for free.

Pills

Each color and position of Pill has a different effect. The effects are unknown until taken and are randomized on each run.

Name	Effect
Bad Trip	Isaac takes a Half-Heart of damage.
Balls of Steel	Isaac gains two Soul Hearts.
Bombs are Key	Isaac's Bomb count and Key count are swapped.
Explosive Diarrhea	Isaac drops Troll bombs for a short amount of time.
Full Health	Isaac's Red Heart Containers are restored.
Health Down	Isaac loses a Red Heart Container.
Health Up	Isaac gains a Red Heart Container.
I Found Pills	Isaac gains a stupid face.
Puberty	Isaac gains pubic hairs on his head.
Pretty Fly	Isaac gains a fly orbital, similar to Halo of Flies.
Range Down	Isaac's Range stat is lowered.
Range Up	Isaac's Range stat is raised.
Speed Down	Isaac's Speed stat is lowered.
Speed Up	Isaac's Speed stat is increased.
Tears Down	Isaac's Tears stat is lowered.
Tears Up	Isaac's Tears stat is raised.
Luck Down	Isaac's Luck stat is lowered.
Luck Up	Isaac's Luck stat is increased.
Telepills	Isaac is teleported to a random room. These do not drop on Greed Mode.
48 Hour Energy	Two Batteries spawn near Isaac.
Hematemesis	Isaac's Red Heart Containers are drained all but one and several Red Hearts drop around him.
Paralysis	Isaac cannot move or shoot for a small amount of time.
I can see forever!	Secret Rooms are revealed and opened automatically for the current Floor.
Pheromones	All enemies in the room are charmed and attack each other.
Amnesia	The map is hidden (Curse of the Lost) for the current Floor.
Lemon Party	A large puddle of urine/lemon juice spawns under Isaac. It acts as creep.
R U A Wizard?	Isaac shoots from the sides of his head in diagonal directions.
Percs!	???
Addicted!	???
Re-Lax	Isaac spawns poop behind him for a small amount of time.
???	???
One makes you larger	Isaac's size increases.
One makes you small	Isaac's size decreases.
Infested?	Isaac spawns some spiders.
Infested!	Isaac spawns some spiders.
Power Pill!	Isaac gains the Game Kid effect for a short amount of time.
Retro Vision	Isaac's vision is pixelated for a short amount of time. It does this randomly for the current Floor.

Runes

Runes are small, purple stones that have different effects. They are all unlocked by Challenges.

Name	Image	Effect
Algiz	Resistance	Isaac gains invincibility for 30 seconds.
Ansuz	Vision	The whole map is revealed.
Berkano	Companionship	3 Attack Spiders and 3 Attack Flies are spawned.
Dagaz	Purity	All Curses are removed from the Floor (including Amnesia). Isaac also gains one Soul Heart.
Ehwaz	Passage	A trap door to the next Floor is opened.
Hagalaz	Destruction	All obstacles in the room are destroyed.
Jera	Abundance	Copies of all Pickups (including Chests and Consumables) in the Room are created, even in Shops where the Items are purchased yet.
Perthro	Change	All Collectibles in the Room are re-rolled.
Blank Rune	???	A random Rune is used.

Misc.

Miscellaneous consumables are consumables that aren't Runes, Pills, or Cards.

Name	Image	Effect
Dice Shard		Re-rolls all Pickups and Collectibles in the Room.
Emergency Contact	Help from above	Mom's hands come down and grab enemies, not allowing them to move.