The Holy Leech is an enemy in The Binding of Isaac: Rebirth that is commonly found on The Womb, the Utero, The Scarred Womb, the Sheol, and the Cathedral floors. It randomly floats around the room until Isaac is in its cardinal directions, in which it will charge at Isaac. It has an Eternal Fly that orbits around it. The Holy Leech explodes on death, sometimes causing chain reactions. It can't fly over rocks, but it flies over spikes and holes.